Flea & Tick Treatments

FRONTLINE Plus Flea and Tick Treatment for Large Dogs (45–88 lbs) – 3 Treatments

Keep your large dog protected with FRONTLINE Plus, the #1 name in flea and tick protection, trusted by pet owners and veterinarians for nearly 20 years. This pack delivers 3 monthly treatments — a full 3-month supply — specially formulated for dogs weighing 45–88 lbs.

FRONTLINE Plus combines two powerful active ingredients — fipronil and (S)-methoprene — to break the flea life cycle at every stage. Fipronil quickly kills adult fleas and ticks by attacking their nervous system, while (S)-methoprene works to prevent flea eggs from hatching and stops larval development, guarding against future infestations. This dual-action approach doesn't just treat existing pests — it actively stops new ones from taking hold.

Applied to a single spot between your dog's shoulder blades, the treatment is absorbed into the sebaceous (oil) glands beneath the skin, which act as a natural reservoir — continuously replenishing protection over your dog's entire body, even after swimming or bathing. FRONTLINE Plus effectively controls major tick species, including brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which can transmit Lyme disease), as well as chewing lice, and helps manage sarcoptic mange with regular use.

✨ Key Highlights:

• 3 treatments — a full 3-month supply
• For dogs and puppies 8 weeks or older, weighing 45–88 lbs
• Active ingredients: Fipronil 9.8% and (S)-methoprene 8.8%
• Kills fleas, flea eggs, flea larvae, chewing lice, and ticks
• Waterproof and long-lasting — one dose per month
• Trusted flea & tick brand for over 20 years
• Fast-acting, easy single-spot application
• No prescription required

Frontline Plus Flea & Tick Spot Treatment for Cats, over 1.5 lbs, 3 Doses (3-Month Supply)

Trust the #1 name in flea and tick protection with Frontline Plus for Cats, a long-lasting, fast-acting, waterproof treatment relied upon by pet owners for over 20 years. This 3-dose pack provides a full 3-month supply of complete parasite protection for cats and kittens weighing 1.5 lbs and over.

Frontline Plus is proven to kill adult fleas, flea eggs, flea larvae, chewing lice, and ticks — including ticks that may transmit Lyme disease. Its dual active-ingredient formula, combining fipronil and (S)-methoprene, breaks the flea life cycle at every stage, effectively eliminating existing fleas while preventing new infestations from developing. One simple topical application delivers a full 30 days of continuous protection, making it a reliable, low-maintenance solution for busy pet owners.

Designed for cats and kittens 8 weeks or older, Frontline Plus is easy to apply directly to the skin and remains effective even after bathing or swimming thanks to its waterproof formula. Whether your cat spends time indoors, outdoors, or both, this treatment offers dependable, long-lasting defense against fleas and ticks all season long.

✨ Key Highlights:

• 3 doses — a full 3-month supply
• For cats and kittens 8 weeks or older, weighing 1.5 lbs and over
• Kills adult fleas, flea eggs, flea larvae, chewing lice, and ticks
• Two active ingredients: fipronil and (S)-methoprene
• Breaks the flea life cycle to prevent re-infestation
• Waterproof, long-lasting protection — one application lasts 30 days
• Trusted brand with 20+ years of proven results

Elanco Advantage II Flea Treatment for Large Cats (9+ lbs), 4 Doses

Give your large cat vet-recommended protection against fleas with Advantage II, a leading topical flea treatment trusted by pet owners and veterinarians alike. Specially formulated for cats over 9 lbs, this 4-dose pack provides four monthly applications — a full 4-month supply of complete flea protection in one convenient purple package.

Advantage II works fast, killing fleas through contact so they don't have to bite your cat to die, with visible results starting within 12 hours of application. Its dual-action formula targets fleas at every life stage — killing adult fleas, flea larvae, and flea eggs to deliver total flea protection, effectively breaking the flea life cycle and helping to prevent re-infestation in both your cat and your home. The active ingredients are Imidacloprid 9.1% and Pyriproxyfen 0.46%, working together to eliminate existing fleas and stop new ones from developing. Advantage II Large Cat +4

Monthly use of Advantage II is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia. Application is simple — this convenient, spot-on application goes on the back of your cat's neck at the base of the skull; simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It's fragrance-free and waterproof after 24 hours of application, and effective for both indoor and outdoor cats. Advantage® II Flea Prevention & Treatment for Large Cats over 9 lbs, Monthly Doses +2

✨ Key Highlights:

• 4 doses — a full 4-month supply
• Approved for cats at least 8 weeks old and weighing over 9 lbs fbn
• Kills adult fleas, flea larvae, and flea eggs
• Fast-acting: kills fleas within 12 hours
• Fragrance-free and waterproof after 24 hours petsmart
• No prescription needed — available over-the-counter petsmart
• Easy monthly spot-on application, no pills required

K9 Advantix II Medium Dog – Vet-Recommended Flea, Tick & Mosquito Treatment & Prevention | Dogs 11–20 lbs.

Keep your medium-sized dog protected all season long with K9 Advantix II, a veterinarian-recommended, once-monthly topical treatment specially formulated for dogs weighing 11–20 lbs. This broad-spectrum solution doesn't just repel pests — it actively kills and repels fleas, ticks, and mosquitoes, while also defending against biting flies and lice, making it a comprehensive shield against five common parasites in one easy application.

Powered by a proven combination of active ingredients — Imidacloprid, Permethrin, and Pyriproxyfen — K9 Advantix II gets straight to work, killing fleas on contact within 12 hours of application. This contact-kill action means fleas don't need to bite your dog to die, helping to stop existing infestations and prevent new ones by targeting all flea life stages, including eggs and larvae. The formula also helps protect against the transmission of tapeworms, Flea Allergy Dermatitis, and flea bite anemia.

Application couldn't be simpler: this fragrance-free, spot-on topical treatment applies directly to your dog's skin in seconds — no pills to force down, no collar to fuss with. Once applied, it becomes waterproof after 24 hours, maintaining its effectiveness through baths, swimming, and rainy days. Suitable for both indoor and outdoor dogs aged 7 weeks and older, K9 Advantix II is available over-the-counter, with no prescription required.

✨ Key Highlights:

• Vet-recommended monthly topical treatment
• Kills and repels fleas, ticks, and mosquitoes
• Also protects against biting flies and lice
• Active ingredients: Imidacloprid, Permethrin, Pyriproxyfen
• Kills fleas within 12 hours of application
• Fragrance-free and waterproof after 24 hours
• For dogs 11–20 lbs., 7 weeks or older
• No prescription needed — available over-the-counter